Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid

• Keunsoo Kim,
• Venkateshwarlu Punna,
• Phaneendrasai Karri and
• Ramanarayanan Krishnamurthy

Beilstein J. Org. Chem. 2014, 10, 2131–2138, doi:10.3762/bjoc.10.220

• nucleic acids; isoGNA; oligonucleotides; phosphoramidites; Introduction Acyclic nucleic acids have garnered a lot of attention and are becoming an important component in nucleic acid chemistry [1][2][3]. Lately, there has been an explosion in the number of investigated candidates [4][5][6][7]. We have

• the adenine derivative. The synthetic improvements described here enable an easy access to isoGNA and allows for the further exploration of this structural unit in oligonucleotide chemistry thereby spurring investigations of its usefulness and applicability. Keywords: acyclic nucleic acids; glycerol