Beilstein J. Org. Chem.2014,10, 2131–2138, doi:10.3762/bjoc.10.220
nucleicacids; isoGNA; oligonucleotides; phosphoramidites; Introduction
Acyclic nucleic acids have garnered a lot of attention and are becoming an important component in nucleic acid chemistry [1][2][3]. Lately, there has been an explosion in the number of investigated candidates [4][5][6][7]. We have
the adenine derivative. The synthetic improvements described here enable an easy access to isoGNA and allows for the further exploration of this structural unit in oligonucleotide chemistry thereby spurring investigations of its usefulness and applicability.
Keywords: acyclic nucleic acids; glycerol
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Graphical Abstract
Figure 1:
A constitutional and conformational (idealized) representation of isoGNA, an isomer of glycerol nuc...